Daniel Griffin, MD, PhD
ACADEMIC TITLE: Associate Research Scientist and Instructor in Clinical Medicine
University of Colorado, BA
New York University School of Medicine, MD
Elmezzi School of Molecular Medicine, The Feinstein Institute, PhD
RESEARCH AND CLINICAL SUMMARY:
Dr. Griffin is a member of the Division of Infectious Diseases and an Associate Research Scientist in the Department of Biochemistry and Molecular Biophysics at Columbia University.
Dr. Griffin’s current research focuses on HIV-1 and stem cell latency as well as stem cell gene therapy utilizing retroviral vectors. His other work includes investigating the potential role of human B1 cells and natural antibodies in development of HIV-associated malignancies. In the area of global health, Dr. Griffin is an expert in tropical diseases and is active seeing patients overseas as well as traveler’s immmigrants and residents in the United States.
Dr. Griffin is actively involved in medical education and is one of the hosts and regular contributors to “This week in Parasitism” a podcast about eukaryotic parasites and infectious diseases clinical case studies.
Griffin DO, Metzger M, Bharti B, Dharsee A, Rico JC, McGowan J. Co-infection with Hepatitis C Virus Increases Mortality in HIV-1 Infected Patients Through Increased Liver-Related Deaths Rather Than By Increasing Malignancy Related Deaths. J AIDS and Clin Res 2016, 7:4.
Griffin, D.O. and Goff, S.P. Restriction of HIV-1-based Lentiviral Vectors in Adult Primary Marrow-Derived and Peripheral Mobilized Human CD34+ Hematopoietic Stem and Progenitor Cells Occurs Prior to Viral DNA Integration. Retrovirology 2016 (1);14. PMID 26945863
Rico JC, Schwartz RM, McGowan J, Griffin DO. The Presence of a Malignant Comorbidity is a Significant Predictor of Increased 30-Day Hospital Readmission Rates in HIV-1 Infected Individuals. J AIDS and Clin Res 2015, 6:12. DOI: 10.4172/2155-6113.1000532
Griffin DO, Metzger M, Poeth K, Deng K, Dharsee A, Rico JC, McGowan J. Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy. OFID 2015,2:ofv147. DOI: 10.1093/ofid/ofv147
Cui X., Zhang L., Magli A. R., Catera R., Yan X. J., Griffin D. O., Rothstein T. L., Barrientos J., Kolitz J. E., Allen S. L., Rai K. R., Chiorazzi N. and Chu C. C. (2015) Cytoplasmic myosin exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia 2015 July 29. DOI: 10.1038/leu.2015.204.
Griffin, D.O. and Goff, S.P. HIV-1 is Restricted Prior to Integration in Primary Cord-Derived Human CD34+ Cells. J Virol 2015 May 20. Pii JVI.0.01044-15.
Griffin, D.O., Dharsee, A., Rico, J.C., McGowan, J., The Increasing Frequency of Deaths Due to Malignancy in HIV+ Patients is Associated with Poor Viral Suppression, Low CD4 Counts, Decreased Vitamin D Levels and Integrase Inhibitor Therapy. Journal of Health Science 2 (2014) 240-247. DOI: 10.17265/2328-7136/2014.05.005
Griffin, D.O. and T.L. Rothstein, Human "orchestrator" CD11b(+) B1 cells spontaneously secrete IL-10 and regulate T cell activity. Molecular Medicine, 2012 Sep 7;18:1003-8. PMID 22634719
Griffin, D.O. and T.L. Rothstein, Human B1 cell Frequency: Isolation and Analysis of Human B1 Cells. Frontiers in Immunology, 2012. 3(122): p. 1-10. Epub 2012 May25. PMID 22634719
Griffin, D.O., T. Quach, F. Batliwalla, N.E. Holodick, and T.L. Rothstein. 2012. Human CD11b+ B1 cells are not monocytes: A reply to “Gene profiling of CD11b+ and CD11b- B1 cell subsets reveals potential cell sorting artifacts". J Exp Med. 209:434-436. PMID 22412176
Griffin, D.O., and T.L. Rothstein. 2011. A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus. J Exp Med. 208:2591-8. PMID 22110167
Griffin, D.O., N.E. Holodick, and T.L. Rothstein. 2011. Human B1 cells are CD3-: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells". J Exp Med. 208:2566-9. PMID 22184682
Griffin, D.O., N.E. Holodick, and T.L. Rothstein. 2011. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70. J Exp Med. 208:67-80. PMID 21220451
Doing A, Griffin D, Jacobson JA, Amber IJ, Gilbert E. 2001, B-cell function in chronic heart failure: antibody response to pneumococcal vaccine. J Card Fail 7:318-21. PMID 11782854